Archive for November, 2010

An HIV vaccine

Tuesday, November 23rd, 2010

I was thinking of how to develop one vaccine for HIV, all the sudden, there is this news all over the world, which is a very good news indeed. I’m very curious of at the atomic level, how does this drug work? Any resistance this virus may develop? Any improvement, for example, instead of taking daily, taking weekly or monthly, I mean, as less as possible so it could be more efficient?

Also, the mutagenesis affect of this drug should also be considered, especially, long-term effect.

Reading “A CV of failures”

Sunday, November 21st, 2010

This essay is quite interesting. Here is an excerpted part:

So here is my suggestion. Compile an ‘alternative’ CV of failures. Log every unsuccessful application, refused grant proposal and rejected paper. Don’t dwell on it for hours, just keep a running, up-to-date tally. If you dare — and can afford to — make it public. It will be six times as long as your normal CV. It will probably be utterly depressing at first sight. But it will remind you of the missing truths, some of the essential parts of what it means to be a scientist — and it might inspire a colleague to shake off a rejection and start again.

In a sense, I could interpret the author’s suggestion in a slightly different way: let’s publish our negative results, i.e., negative application results, negative research results, and by doing so, other people might be benefited, psychologically, scientifically, or both. But I have to say that this is a rather personal thing, seeing so many failures, will I be excited about my future or rather depressed?

not a good one: “Samuel Adams: A Life”

Thursday, November 11th, 2010

This suppose to be a biography, but the author gave too much writing to the context so that it seems it is rather a biography of that time instead of the person of interests. Maybe this is a new style or something, it just doesn’t work for me.

Anyway, Samuel Adams seems an interesting figure, I’ll try to read books about him if there is a good one and I have time.

Need for a HIV-1 vaccine

Sunday, November 7th, 2010

It would be disheartened for me to not think more about the problem after read the NY Time’s paper on HIV baby survivors. Life is surely imaginable for those kids who were born with HIV. Many notorious side-effect of medicines on them, in particular they have to take those medicines for life long, mental tortures of the disease on them, and harsh social environment surrounding them,  …, I can’t help asking the old question, is there anything to cure? And equally urgent, is there anything to prevent getting the disease at first place?

I sincerely hope the paper I read yesterday on Science holing the key to invent such a vaccine. I’m very much motivated to do something about it because it seems that we have the tools and data we need to start tackle the problem. A quintessential data mining coupling with statistical analysis, a fairly reasonable thermophysical model,  massive computer resource, to me it seems we could turn this tide. WOW, very excited with such a possibility of beating the beast.